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JAC Advance Access originally published online on August 30, 2007
Journal of Antimicrobial Chemotherapy 2007 60(5):1172-1173; doi:10.1093/jac/dkm315
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© Crown Copyright 2007. Reproduced with the permission of the Controller of Her Majesty's Stationery Office

Correspondence

Results of a UK survey of fatal anaphylaxis after oral amoxicillin

Paul Lee1,* and David Shanson2

1 Medicines and Healthcare products Regulatory Agency, Market Towers, 1 Nine Elms Lane, London SW5 8NQ, UK 2 Department of Medical Microbiology, Great Ormond Street Hospital for Sick Children, London WC1N 3JH, UK

* Corresponding author. Tel: +44-207-084-2874; E-mail: paul.lee@mhra.gsi.gov.uk

Keywords: BSAC guidelines , prevention , endocarditis , dental procedures

The first 10% of the full text of this article appears below.

Sir,

A single high dose of oral amoxicillin has been the main antibiotic regimen recommended for the prophylaxis of endocarditis since 1982,1 and there has been good compliance with this recommendation in the UK.2 However, the fear that the number of deaths from anaphylaxis associated with amoxicillin prophylaxis could exceed the number of deaths from endocarditis that might be prevented from prophylaxis was one factor leading the BSAC Working Party to discontinue recommending prophylaxis for most susceptible cardiac patients undergoing dental . . . [Full Text of this Article]

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D. C. Shanson
Comment on: New guidance from NICE regarding antibiotic prophylaxis for infective endocarditis - response by the BSAC Working Party
J. Antimicrob. Chemother., March 1, 2009; 63(3): 629 - 630.
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