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JAC Advance Access originally published online on May 4, 2007
Journal of Antimicrobial Chemotherapy 2007 60(1):175-176; doi:10.1093/jac/dkm118
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© The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Correspondence

Comment on: Triclosan resistance in methicillin-resistant Staphylococcus aureus expressed as small colony variants: a novel mode of evasion of susceptibility to antiseptics

Paul F. Seaman1, Dietmar Ochs2 and Martin J. Day1,*

1 Cardiff School of Biosciences, Cardiff University, Park Place, Cardiff CF10 3TL, UK 2 Ciba Spezialitätenchemie Grenzach GmbH, Postfach 1266, D-79630 Grenzach-Wyhlen, Germany

* Corresponding author. Tel: +44-29-20-875768; Fax: +44-29-20-874305; E-mail: day@cardiff.ac.uk

Keywords: S. aureus , MRSA , SCVs , triclosan , antiseptics , biocide resistance

The first 10% of the full text of this article appears below.

Sir,

In their recent article, Bayston et al.1 provide an interesting report on the occurrence of small colony variants (SCVs) of Staphylococcus aureus during exposure to silicone impregnated with triclosan. In parallel with our prior report2 Bayston et al. describe the isolation of SCVs with low-level resistance to triclosan, reduced coagulase production, reduced haemolytic activity and did not detect auxotrophy. They recognize, as others have done, the possible clinical importance of SCVs and the potential role of triclosan in their generation. However, we would like to urge some caution . . . [Full Text of this Article]

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