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JAC Advance Access originally published online on April 21, 2007
Journal of Antimicrobial Chemotherapy 2007 59(6):1182-1184; doi:10.1093/jac/dkm099
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© The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Resveratrol inhibition of Propionibacterium acnes

John J. Docherty1,*, Heather A. McEwen1, Thomas J. Sweet1, Erin Bailey1 and Tristan D. Booth2

1 Department of Microbiology, Immunology and Biochemistry, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, Rootstown, OH 44272, USA 2 Royalmount Pharma, Inc., 6111 Royalmount Avenue, Montreal, Quebec, Canada H4P 2T4

Received 29 January 2007; returned 6 March 2007; revised 9 March 2007; accepted 12 March 2007

* Corresponding author. Tel: +1-330-325-6133; Fax: +1-330-325-5914; E-mail: jjd{at}neoucom.edu

Objectives: To evaluate the effects of the anti-inflammatory hydroxystilbene, resveratrol, on Propionibacterium acnes growth.

Methods: Three different strains of P. acnes were tested against resveratrol at concentrations between 0 and 200 mg/L. Piceatannol was included as a second hydroxystilbene to compare with resveratrol, and erythromycin and benzoyl peroxide were used as positive controls.

Results: After 24 h of treatment with resveratrol, the average 50% inhibitory concentration (IC50) was 73 mg/L and the average 100% inhibitory concentration (IC100) was 187 mg/L for the three strains of P. acnes tested. The IC50 and IC100 of piceatannol were 123 and 234 mg/L, respectively. The highest concentration of resveratrol tested (200 mg/L) was bactericidal, whereas lower concentrations were bacteriostatic.

Conclusions: Resveratrol, an anti-inflammatory hydroxystilbene, is capable of inhibiting P. acnes growth.

Keywords: antimicrobial activity , drug development , human disease


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