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JAC Advance Access originally published online on February 28, 2007
Journal of Antimicrobial Chemotherapy 2007 59(5):1038-1039; doi:10.1093/jac/dkm034
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© The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Correspondence

Increased incidence of class 1 integrons in trimethoprim/sulfamethoxazole-resistant clinical isolates of Stenotrophomonas maltophilia

Lin-Li Chang1,*, Hui-Hui Lin1, Chung-Yu Chang1 and Po-Liang Lu2

1 Faculty of Medicine, Department of Microbiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China 2 Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, Republic of China

* Corresponding author. Tel: +886-7-3121101 ext. 2150; Fax: +886-7-3218309; E-mail: m725006@kmu.edu.tw

Keywords: quaternary ammonium compounds , sul1 , S. maltophilia

The first 10% of the full text of this article appears below.

Sir,

This study found that 21% of Stenotrophomonas maltophilia carry a class 1 integron when integrase-specific primers for intI1 or intI21 were used.

S. maltophilia is a non-fermentative, Gram-negative bacillus, increasingly identified as a nosocomial pathogen in compromised patients. Trimethoprim/sulfamethoxazole is one of the most potent agents for treating S. maltophilia infection. However, resistance to trimethoprim/sulfamethoxazole is apparently increasing.2

Integrons capture genes as part of a genetic element known as a . . . [Full Text of this Article]

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M. E. Falagas, P.-E. Valkimadi, Y.-T. Huang, D. K. Matthaiou, and P.-R. Hsueh
Therapeutic options for Stenotrophomonas maltophilia infections beyond co-trimoxazole: a systematic review
J. Antimicrob. Chemother., November 1, 2008; 62(5): 889 - 894.
[Abstract] [Full Text] [PDF]