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JAC Advance Access originally published online on February 16, 2007
Journal of Antimicrobial Chemotherapy 2007 59(4):751-754; doi:10.1093/jac/dkl547
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© The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Prevalence of qnr genes in Salmonella in France

Vincent Cattoir1,2, François-Xavier Weill3, Laurent Poirel1, Laëtitia Fabre3, Claude-James Soussy2 and Patrice Nordmann1,*

1 Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris XI, K.-Bicêtre, France 2 Service de Bactériologie-Virologie-Hygiène, Hôpital Henri Mondor, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine de Créteil, Université Paris XII, Créteil, France 3 Centre National de Référence des Salmonella, Unité Biodiversité des Bactéries Pathogènes Emergentes, Institut Pasteur, Paris, France

Received 30 November 2006; returned 11 December 2006; revised 14 December 2006; accepted 15 December 2006

* Correspondence address. Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78, rue du Général Leclerc, 94275 Le Kremlin-Bicêtre, France. Tel: +33-1-45-21-36-32; Fax: +33-1-45-21-63-40; E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr

Objectives: To detect the qnrA, qnrB and qnrS genes among Salmonella isolates received at the French National Reference Centre for Salmonella in Paris, France.

Methods: Antibiotic susceptibility was determined by disc diffusion for 499 Salmonella isolates including 320 Salmonella Typhimurium, 100 Salmonella Enteritidis and 79 Salmonella Hadar collected in 2002. Amplification with specific primers of qnrA, qnrB and qnrS genes was performed for all Salmonella Typhimurium, Salmonella Enteritidis and Salmonella Hadar isolates resistant to quinolones and for 17 additional isolates that produced expanded-spectrum ß-lactamases (ESBLs).

Results: Prevalence of quinolone resistance was 3.75%, 11% and 79.7% for Salmonella Typhimurium, Salmonella Enteritidis and Salmonella Hadar serovars, respectively. A single isolate (0.2%) was qnrA-positive (QnrA1 determinant) being a Salmonella serovar Concord carrying also the ESBL gene blaCTX-M-15. This strain was probably from East Africa. No qnrB or qnrS genes were identified.

Conclusions: Whereas plasmid-mediated quinolone resistance of the Qnr type is emerging in Enterobacteriaceae worldwide, it remains rare in Salmonella in France.

Keywords: serovar Concord , qnrA1 , CTX-M-15


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