JAC Advance Access originally published online on December 21, 2006
Journal of Antimicrobial Chemotherapy 2007 59(2):321-322; doi:10.1093/jac/dkl481
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Correspondence |
Multiplex PCR for rapid detection of genes encoding acquired metallo-ß-lactamases
Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, London, UK
* Corresponding author. Tel: +44-20-8327-7259; Fax: +44-20-8200-7449; E-mail: matthew.ellington@hpa.org.uk
Keywords: imipenem , carbapenems , acquired resistance , IMP , VIM
| The first 10% of the full text of this article appears below. |
Sir,
Carbapenems are considered a last-line agent for the treatment of serious Gram-negative sepsis. Metallo-ß-lactamases (MBLs) hydrolyse carbapenems efficiently and, when present, can undermine carbapenem therapy.1 Acquired MBLs have been reported mainly in clinical isolates of Pseudomonas aeruginosa and Acinetobacter spp., sometimes from major clonal outbreaks, as well as in other non-fermenters; they have also been reported, less commonly, in members of the Enterobacteriaceae.2 The acquired MBLs so far described belong to five different families3,4 with multiple variants of the VIM and
Transparency declarations
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  P. G. Higgins, L. Poirel, M. Lehmann, P. Nordmann, and H. Seifert OXA-143, a Novel Carbapenem-Hydrolyzing Class D {beta}-Lactamase in Acinetobacter baumannii Antimicrob. Agents Chemother., December 1, 2009; 53(12): 5035 - 5038. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-L. Lu, M. Doumith, D. M. Livermore, T.-P. Chen, and N. Woodford Diversity of carbapenem resistance mechanisms in Acinetobacter baumannii from a Taiwan hospital: spread of plasmid-borne OXA-72 carbapenemase J. Antimicrob. Chemother., April 1, 2009; 63(4): 641 - 647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Doumith, M. J. Ellington, D. M. Livermore, and N. Woodford Molecular mechanisms disrupting porin expression in ertapenem-resistant Klebsiella and Enterobacter spp. clinical isolates from the UK J. Antimicrob. Chemother., April 1, 2009; 63(4): 659 - 667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Woodford, J. Zhang, M. E. Kaufmann, S. Yarde, M. d. M. Tomas, C. Faris, M. S. Vardhan, S. Dawson, S. L. Cotterill, and D. M. Livermore Detection of Pseudomonas aeruginosa isolates producing VEB-type extended-spectrum {beta}-lactamases in the United Kingdom J. Antimicrob. Chemother., December 1, 2008; 62(6): 1265 - 1268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Livermore, R. Hope, G. Brick, M. Lillie, R. Reynolds, and on behalf of the BSAC Working Parties on Resistanc Non-susceptibility trends among Enterobacteriaceae from bacteraemias in the UK and Ireland, 2001-06 J. Antimicrob. Chemother., November 1, 2008; 62(suppl_2): ii41 - ii54. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Livermore, R. Hope, G. Brick, M. Lillie, R. Reynolds, and on behalf of the BSAC Working Parties on Resistanc Non-susceptibility trends among Pseudomonas aeruginosa and other non-fermentative Gram-negative bacteria from bacteraemias in the UK and Ireland, 2001-06 J. Antimicrob. Chemother., November 1, 2008; 62(suppl_2): ii55 - ii63. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nemec, L. Krizova, M. Maixnerova, L. Diancourt, T. J. K. van der Reijden, S. Brisse, P. van den Broek, and L. Dijkshoorn Emergence of carbapenem resistance in Acinetobacter baumannii in the Czech Republic is associated with the spread of multidrug-resistant strains of European clone II J. Antimicrob. Chemother., September 1, 2008; 62(3): 484 - 489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-L. Chen, R. C.-C. Wu, M.-F. Shaio, C.-P. Fung, and W.-L. Cho Acquisition of a Plasmid-Borne blaOXA-58 Gene with an Upstream IS1008 Insertion Conferring a High Level of Carbapenem Resistance to Acinetobacter baumannii Antimicrob. Agents Chemother., July 1, 2008; 52(7): 2573 - 2580. [Abstract] [Full Text] [PDF]
|
|