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JAC Advance Access originally published online on December 1, 2006
Journal of Antimicrobial Chemotherapy 2007 59(1):159-160; doi:10.1093/jac/dkl462
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Correspondence

Human intravenous immunoglobulin for experimental streptococcal toxic shock: bacterial clearance and modulation of inflammation—author's response

Shiranee Sriskandan*

Department of Infectious Diseases and Immunity, Hammersmith Hospital, Imperial College London Du Cane Road, London W12 0NN, UK

*Correponding author. Tel: +44-208-383-3135; Fax: +44-208-383-3394; E-mail: s.sriskandan@imperial.ac.uk

Keywords: bacterial infections , models , septic shock , Streptococcus pyogenes , immunology , immunomodulators

The first 10% of the full text of this article appears below.

Sir,

The failure of Rajagopalan et al.1 to demonstrate any effect of intravenous immunoglobulin (IVIg) in vitro is perplexing, as several investigators have demonstrated the inhibitory properties of IVIg on superantigen-induced T cell mitogenesis and blast formation in vitro.2–6 Although variation in IVIg source may partly explain their results, the . . . [Full Text of this Article]

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