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JAC Advance Access originally published online on December 20, 2005
Journal of Antimicrobial Chemotherapy 2006 57(2):364-365; doi:10.1093/jac/dki465
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Correspondence

Evaluation of six fluoroquinolones for their capabilities in restricting the selection of resistant salmonellae

J. M. Ling* and Y. Jin{dagger}

Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China

* Corresponding author. Tel: +852-2632-3333; Fax: +852-2647-3227; E-mail: meilunling@cuhk.edu.hk

Keywords: mutant prevention concentration , Salmonella Typhimurium , Salmonella Hadar , gemifloxacin , moxifloxacin

The first 10% of the full text of this article appears below.

Sir,

Mutant prevent concentration (MPC), a recently developed concept,1 is defined as the minimum concentration of an antibiotic that can inhibit growth of mutants from amongst 1010 colonies. MPC/MIC ratio is an index to predict the size of the mutant selection window (MSW) within which susceptible bacterial cells are inhibited but resistant mutants multiply and grow rapidly.1 The narrower the MSW of a drug, the greater is its potential to restrict selection of resistant mutants.

Fluoroquinolones are now the drugs of choice . . . [Full Text of this Article]

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