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JAC Advance Access originally published online on October 21, 2005
Journal of Antimicrobial Chemotherapy 2006 57(1):150-151; doi:10.1093/jac/dki394
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Correspondence

Linezolid use in sepsis due to methicillin-susceptible Staphylococcus aureus

C. De Gascun*, L. Rajan, E. O'Neill and E. G. Smyth

Department of Clinical Microbiology, Beaumont Hospital, Dublin, Ireland


* Corresponding author. E-mail: cfbdeg@hotmail.com

Keywords: S. aureus , cytokines , exotoxins , antimicrobial activity

The first 10% of the full text of this article appears below.

Sir,

We read with interest the correspondence from De Bels et al.1 Given the tissue penetration data available on the two agents in question, however, it is not surprising that linezolid proved to be successful where vancomycin had failed in a case of septic arthritis.2 We present a similar case, but of methicillin-susceptible Staphylococcus aureus (MSSA)-induced sepsis, which only responded to antimicrobial therapy after linezolid had been added to a regimen of flucloxacillin, fusidic . . . [Full Text of this Article]

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Effect of severity of sepsis on tissue concentrations of linezolid
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J Antimicrob ChemotherHome page
V. O. De Beeck, N. Dhif, J. Philipp, and D. De Bels
Comment on: Linezolid use in sepsis due to methicillin-susceptible Staphylococcus aureus
J. Antimicrob. Chemother., March 1, 2006; 57(3): 577 - 577.
[Full Text] [PDF]