Skip Navigation


JAC Advance Access originally published online on December 6, 2005
Journal of Antimicrobial Chemotherapy 2006 57(1):1-3; doi:10.1093/jac/dki425
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
57/1/1    most recent
dki425v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (52)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Brown, S.
Right arrow Articles by Amyes, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brown, S.
Right arrow Articles by Amyes, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Leading article

OXA ß-lactamases in Acinetobacter: the story so far

Susan Brown and Sebastian Amyes*

Molecular Chemotherapy, Centre for Infectious Diseases, University of Edinburgh, The Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK

* Corresponding author. Tel: +44-131-242-6652; Fax: +44-131-242-6611; E-mail: s.g.b.amyes{at}ed.ac.uk

The emergence of carbapenem resistance in Acinetobacter baumannii has become a global concern since these ß-lactams are often the only effective treatment left against many multiresistant strains. A recent development has been the discovery of a novel group of narrow-spectrum OXA ß-lactamases in carbapenem-resistant strains, some of which have acquired the ability to hydrolyse the carbapenems. The first of these was found in a strain isolated in Edinburgh before imipenem was in use in the hospital. Whether these carbapenemases have been acquired or are part of the genetic make-up of this species has yet to be determined. More importantly, however, they represent an important stage in the evolution of antibiotic resistance in Acinetobacter. This paper discusses the emergence of these unusual enzymes over the past decade.

Keywords: Acinetobacter , OXA-type ß-lactamases , carbapenem resistance


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Antimicrob. Agents Chemother.Home page
P. G. Higgins, L. Poirel, M. Lehmann, P. Nordmann, and H. Seifert
OXA-143, a Novel Carbapenem-Hydrolyzing Class D {beta}-Lactamase in Acinetobacter baumannii
Antimicrob. Agents Chemother., December 1, 2009; 53(12): 5035 - 5038.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
C. Juan, X. Mulet, L. Zamorano, S. Alberti, J. L. Perez, and A. Oliver
Detection of the Novel Extended-Spectrum {beta}-Lactamase OXA-161 from a Plasmid-Located Integron in Pseudomonas aeruginosa Clinical Isolates from Spain
Antimicrob. Agents Chemother., December 1, 2009; 53(12): 5288 - 5290.
[Abstract] [Full Text] [PDF]

Home page
 J Med MicrobiolHome page
A. K. Mostachio, I. van der Heidjen, F. Rossi, A. S. Levin, and S. F. Costa
Multiplex PCR for rapid detection of genes encoding oxacillinases and metallo-{beta}-lactamases in carbapenem-resistant Acinetobacter spp.
J. Med. Microbiol., November 1, 2009; 58(11): 1522 - 1524.
[Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
P.-L. Lu, M. Doumith, D. M. Livermore, T.-P. Chen, and N. Woodford
Diversity of carbapenem resistance mechanisms in Acinetobacter baumannii from a Taiwan hospital: spread of plasmid-borne OXA-72 carbapenemase
J. Antimicrob. Chemother., April 1, 2009; 63(4): 641 - 647.
[Abstract] [Full Text] [PDF]

Home page
 J Med MicrobiolHome page
D. Gur, V. Korten, S. Unal, L. M. Deshpande, and M. Castanheira
Increasing carbapenem resistance due to the clonal dissemination of oxacillinase (OXA-23 and OXA-58)-producing Acinetobacter baumannii: report from the Turkish SENTRY Program sites
J. Med. Microbiol., December 1, 2008; 57(12): 1529 - 1532.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
C. R. Bethel, A. M. Distler, M. W. Ruszczycky, M. P. Carey, P. R. Carey, A. M. Hujer, M. Taracila, M. S. Helfand, J. M. Thomson, M. Kalp, et al.
Inhibition of OXA-1 {beta}-Lactamase by Penems
Antimicrob. Agents Chemother., September 1, 2008; 52(9): 3135 - 3143.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
P. Marchiaro, V. Ballerini, T. Spalding, G. Cera, M. A. Mussi, J. Moran-Barrio, A. J. Vila, A. M. Viale, and A. S. Limansky
A convenient microbiological assay employing cell-free extracts for the rapid characterization of Gram-negative carbapenemase producers
J. Antimicrob. Chemother., August 1, 2008; 62(2): 336 - 344.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
E. S. Moland, D. W. Craft, S.-g. Hong, S.-y. Kim, L. Hachmeister, S. D. Sayed, and K. S. Thomson
In Vitro Activity of Tigecycline against Multidrug-Resistant Acinetobacter baumannii and Selection of Tigecycline-Amikacin Synergy
Antimicrob. Agents Chemother., August 1, 2008; 52(8): 2940 - 2942.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
A. Y. Peleg, H. Seifert, and D. L. Paterson
Acinetobacter baumannii: Emergence of a Successful Pathogen
Clin. Microbiol. Rev., July 1, 2008; 21(3): 538 - 582.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
T.-L. Chen, R. C.-C. Wu, M.-F. Shaio, C.-P. Fung, and W.-L. Cho
Acquisition of a Plasmid-Borne blaOXA-58 Gene with an Upstream IS1008 Insertion Conferring a High Level of Carbapenem Resistance to Acinetobacter baumannii
Antimicrob. Agents Chemother., July 1, 2008; 52(7): 2573 - 2580.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
C. G. Giske, D. L. Monnet, O. Cars, Y. Carmeli, and on behalf of ReAct-Action on Antibiotic Resistance
Clinical and Economic Impact of Common Multidrug-Resistant Gram-Negative Bacilli
Antimicrob. Agents Chemother., March 1, 2008; 52(3): 813 - 821.
[Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
C. Qi, M. Malczynski, M. Parker, and M. H. Scheetz
Characterization of Genetic Diversity of Carbapenem-Resistant Acinetobacter baumannii Clinical Strains Collected from 2004 to 2007
J. Clin. Microbiol., March 1, 2008; 46(3): 1106 - 1109.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
W. S. Hu, S.-M. Yao, C.-P. Fung, Y.-P. Hsieh, C.-P. Liu, and J.-F. Lin
An OXA-66/OXA-51-Like Carbapenemase and Possibly an Efflux Pump Are Associated with Resistance to Imipenem in Acinetobacter baumannii
Antimicrob. Agents Chemother., November 1, 2007; 51(11): 3844 - 3852.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
H. Wang, P. Guo, H. Sun, H. Wang, Q. Yang, M. Chen, Y. Xu, and Y. Zhu
Molecular Epidemiology of Clinical Isolates of Carbapenem-Resistant Acinetobacter spp. from Chinese Hospitals
Antimicrob. Agents Chemother., November 1, 2007; 51(11): 4022 - 4028.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
F. Perez, A. M. Hujer, K. M. Hujer, B. K. Decker, P. N. Rather, and R. A. Bonomo
Global Challenge of Multidrug-Resistant Acinetobacter baumannii
Antimicrob. Agents Chemother., October 1, 2007; 51(10): 3471 - 3484.
[Full Text] [PDF]

Home page
 J Med MicrobiolHome page
H. Zhou, B.-R. Pi, Q. Yang, Y.-S. Yu, Y.-G. Chen, L.-J. Li, and S.-S. Zheng
Dissemination of imipenem-resistant Acinetobacter baumannii strains carrying the ISAba1 blaOXA-23 genes in a Chinese hospital
J. Med. Microbiol., August 1, 2007; 56(8): 1076 - 1080.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
A. M. Queenan and K. Bush
Carbapenemases: the Versatile {beta}-Lactamases
Clin. Microbiol. Rev., July 1, 2007; 20(3): 440 - 458.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
M. V. Villegas, J. N. Kattan, A. Correa, K. Lolans, A. M. Guzman, N. Woodford, D. Livermore, J. P. Quinn, and and the Colombian Nosocomial Bacterial Resistance
Dissemination of Acinetobacter baumannii Clones with OXA-23 Carbapenemase in Colombian Hospitals
Antimicrob. Agents Chemother., June 1, 2007; 51(6): 2001 - 2004.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
T. H. Koh, L.-H. Sng, G. C. Y. Wang, L.-Y. Hsu, and Y. Zhao
IMP-4 and OXA {beta}-lactamases in Acinetobacter baumannii from Singapore
J. Antimicrob. Chemother., April 1, 2007; 59(4): 627 - 632.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
A. Tsakris, A. Ikonomidis, S. Pournaras, N. Spanakis, and A. Markogiannakis
Carriage of OXA-58 but not of OXA-51 {beta}-lactamase gene correlates with carbapenem resistance in Acinetobacter baumannii
J. Antimicrob. Chemother., November 1, 2006; 58(5): 1097 - 1099.
[Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
P. Bogaerts, T. Naas, I. Wybo, C. Bauraing, O. Soetens, D. Pierard, P. Nordmann, and Y. Glupczynski
Outbreak of Infection by Carbapenem-Resistant Acinetobacter baumannii Producing the Carbapenemase OXA-58 in Belgium
J. Clin. Microbiol., November 1, 2006; 44(11): 4189 - 4192.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
K. Lolans, T. W. Rice, L. S. Munoz-Price, and J. P. Quinn
Multicity Outbreak of Carbapenem-Resistant Acinetobacter baumannii Isolates Producing the Carbapenemase OXA-40.
Antimicrob. Agents Chemother., September 1, 2006; 50(9): 2941 - 2945.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
H. Vahaboglu, F. Budak, M. Kasap, G. Gacar, S. Torol, A. Karadenizli, F. Kolayli, and C. Eroglu
High prevalence of OXA-51-type class D {beta}-lactamases among ceftazidime-resistant clinical isolates of Acinetobacter spp.: co-existence with OXA-58 in multiple centres
J. Antimicrob. Chemother., September 1, 2006; 58(3): 537 - 542.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
J. F. Turton, N. Woodford, J. Glover, S. Yarde, M. E. Kaufmann, and T. L. Pitt
Identification of Acinetobacter baumannii by Detection of the blaOXA-51-like Carbapenemase Gene Intrinsic to This Species.
J. Clin. Microbiol., August 1, 2006; 44(8): 2974 - 2976.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.