Skip Navigation


JAC Advance Access originally published online on October 13, 2005
Journal of Antimicrobial Chemotherapy 2005 56(6):1176-1178; doi:10.1093/jac/dki368
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
56/6/1176    most recent
dki368v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Morales-Molina, J. A.
Right arrow Articles by Grau, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Morales-Molina, J. A.
Right arrow Articles by Grau, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Linezolid-associated serotonin syndrome: what we can learn from cases reported so far

José Antonio Morales-Molina, Javier Mateu-de Antonio, Mónica Marín-Casino and Santiago Grau*

Pharmacy Department, Hospital del Mar, Passeig Marítim, 25–29, 08003 Barcelona, Spain

Received 9 August 2005; returned 30 August 2005; revised 2 September 2005; accepted 15 September 2005

* Corresponding author. Tel: +34-93-248-31-06; Fax: +34-93-248-32-56; E-mail: sgrau{at}imas.imim.es

Objectives: To study the characteristics of the linezolid-associated serotonin syndrome cases.

Methods: Database search for linezolid-associated serotonin syndrome.

Results: Twelve cases were found. The mean age of patients was 52.8 years. All patients received linezolid concomitantly with selective serotonin re-uptake inhibitor drugs (SSRID). The onset of syndrome was 9.5 days after linezolid introduction and was directly correlated to patients' age (P = 0.024). The symptoms resolved in 2.9 days. Citalopram was associated with a delayed resolution (P = 0.018). A trend was observed towards longer resolution time the longer the half-life of the interacting drug (P = 0.096).

Conclusions: Patients are at risk when receiving SSRID concomitant with linezolid. The syndrome onset could be delayed in older patients. The resolution could be delayed when citalopram is involved in the syndrome.

Keywords: citalopram , oxazolidinones , serotonin uptake inhibitors


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 NeurologyHome page
B. F. Shneker, P. D. Baylin, and M. E. Nakhla
LINEZOLID INDUCING COMPLEX PARTIAL STATUS EPILEPTICUS IN A PATIENT WITH EPILEPSY
Neurology, January 27, 2009; 72(4): 378 - 379.
[Full Text] [PDF]

Home page
 The Annals of PharmacotherapyHome page
D. O Maclayton and R. G Hall II
Pharmacologic Treatment Options for Nosocomial Pneumonia Involving Methicillin-Resistant Staphylococcus aureus
Ann. Pharmacother., February 1, 2007; 41(2): 235 - 244.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.