Skip Navigation


JAC Advance Access originally published online on October 13, 2005
Journal of Antimicrobial Chemotherapy 2005 56(6):1069-1073; doi:10.1093/jac/dki359
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
56/6/1069    most recent
dki359v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Piercy, T.
Right arrow Articles by Brooks, T. J. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Piercy, T.
Right arrow Articles by Brooks, T. J. G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© British Crown Copyright 2005, Dstl-published with the permission of the Controller of Her Majesty's Stationery Office.

In vivo efficacy of fluoroquinolones against systemic tularaemia infection in mice

T. Piercy1,*, J. Steward1, M. S. Lever1 and T. J. G. Brooks1,2

1 Biomedical Sciences, Dstl Porton Down, Salisbury SP4 OJQ, UK; 2 HPA Porton Down, Salisbury SP4 OJG, UK

Received 3 May 2005; returned 25 June 2005; revised 9 September 2005; accepted 9 September 2005

* Correspondence address. Room 14, Bldg 245, Dstl Porton Down, Salisbury, Wiltshire SP4 OJQ, UK. Tel: +44-1980-613221; Fax: +44-1980-613284; E-mail: tjpiercy{at}dstl.gov.uk

Objectives: The in vivo efficacy of ciprofloxacin, gatifloxacin and moxifloxacin were assessed in an experimental Francisella tularensis Schu S4 infection in the BALB/c mouse model.

Methods: Mice were given 100 mg/kg of antibiotic by oral administration twice daily commencing at 6, 24 or 48 h post-exposure and continued for 14 days post-exposure. All mice were challenged subcutaneously with 1 x 106 cfu F. tularensis Schu S4 and observed for a period of 56 days.

Results: Treatment initiated 6 h post-exposure resulted in 94, 100 and 100% survival for ciprofloxacin, gatifloxacin and moxifloxacin, respectively. When treatment was delayed until 24 h post-exposure the survival rates were ciprofloxacin 67%, gatifloxacin 96% and moxifloxacin 100%. Treatment initiated at 48 h post-exposure resulted in a significant reduction in the survival rate of the ciprofloxacin-treated mice, with 0% survival compared with 84 and 62% for gatifloxacin and moxifloxacin, respectively. Non-treated infected control mice died within 96 h post-exposure. Dexamethasone given at day 42 for 7 days to suppress the animals' immune system caused relapse in all of the treatment groups.

Conclusions: Both gatifloxacin and moxifloxacin were more effective at preventing mortality than ciprofloxacin and could be considered as alternative antibiotics in the treatment of systemic F. tularensis infection.

Keywords: chemotherapy , fluoroquinolones , murine , quinolones , tularaemia


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.