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JAC Advance Access originally published online on September 2, 2005
Journal of Antimicrobial Chemotherapy 2005 56(4):794-795; doi:10.1093/jac/dki316
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Correspondence

Loss of mecA gene in Staphylococcus epidermidis after prolonged therapy with vancomycin

Parham Sendi*, Peter Graber and Werner Zimmerli

Division of Infectious Diseases, Basel University Medical Clinic, Rheinstrasse 26, CH-4410 Liestal, Switzerland

* Corresponding author. Tel: +41-61-925-34-19; Fax: +41-61-925-28-04; E-mail: sendi-pa@magnet.ch

Keywords: methicillin resistance , S. epidermidis , gene loss , glycopeptides

The first 10% of the full text of this article appears below.

Sir,

The most commonly cultured microorganisms in prosthetic-joint infections are coagulase-negative staphylococci.1 Resistance to ß-lactam antibiotics is encoded by the mecA gene; this gene is carried on a mobile genetic element, the staphylococcal chromosome cassette mec (SCCmec). Loss or deletion of the mecA gene rarely occurs, mainly due to factors affecting the stability of SCCmec. Vancomycin may . . . [Full Text of this Article]

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