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JAC Advance Access originally published online on July 26, 2005
Journal of Antimicrobial Chemotherapy 2005 56(3):602-603; doi:10.1093/jac/dki274
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org

Correspondence

Successful treatment of Acinetobacter meningitis with meropenem and rifampicin

Todd Gleeson1,*, Kyle Petersen1 and John Mascola2

1 Department of Infectious Diseases, National Naval Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889–5600, USA; 2 Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, MD 20892, USA


* Corresponding author. Tel: +1-301-319-8360; Fax: +1-301-295-2992; E-mail: tdgleeson@bethesda.med.navy.mil

Keywords: nosocomial meningitis , post-neurosurgical meningitis , ventriculostomy

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Sir,

Acinetobacter calcoaceticus-baumannii complex is a common cause of nosocomial infections, including post-neurosurgical meningitis. Multidrug-resistant (MDR) Acinetobacter is increasingly common worldwide, presenting a therapeutic challenge. Non-traditional antibiotics, including sulbactam, colistin and polymyxin B, have been used for MDR Acinetobacter meningitis.

Rifampicin demonstrates a bactericidal effect against Acinetobacter baumannii both in vitro as well as in animal models. Rifampicin . . . [Full Text of this Article]

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