JAC Advance Access originally published online on August 8, 2005
Journal of Antimicrobial Chemotherapy 2005 56(3):600-601; doi:10.1093/jac/dki278
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org
Correspondence |
Disc methods for detecting AmpC ß-lactamase-producing clinical isolates of Escherichia coli and Klebsiella pneumoniae
1 Department of Microbiology and 2 Hospital Infection Research Laboratory, City Hospital, Dudley Road, Birmingham, UK
* Corresponding author. Tel: +44-121-507-4228; Fax: +44-121-551-7763; E-mail: nigel.brenwald@swbh.nhs.uk
Keywords: susceptibility testing , ß-lactamase inhibitor , disc diffusion
| The first 10% of the full text of this article appears below. |
Sir,
The increasing prevalence of AmpC ß-lactamase-mediated resistance among Escherichia coli and Klebsiella pneumoniae is of clinical concern.1 Both of these organisms can acquire AmpC ß-lactamases on plasmids and additionally, E. coli can hyper-produce its chromosomal AmpC ß-lactamase, which is normally only produced at very low levels.2 The recognition of AmpC ß-lactamase producers can be difficult, although resistance to cefoxitin can help in identifying them. Unfortunately, cefoxitin resistance is not
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