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JAC Advance Access originally published online on June 21, 2005
Journal of Antimicrobial Chemotherapy 2005 56(2):431; doi:10.1093/jac/dki231
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org

Correspondence

Resistance ratchet effect: author's response

J. T. Magee*

Communicable Diseases Surveillance Centre, Abton House, Wedal Road, Cardiff CF4 3QX, UK

* Corresponding author. Tel: +44-29-2052-1997; Fax: +44-29-2052-1987; E-mail: john.magee@nphs.wales.nhs.uk

Keywords: resistance , surveillance , antibiotic policies , mathematical models

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Sir,

The ratchet model1 predicts a small, unexpected additional effect to straightforward Darwinian selection for antibiotic resistance—a hill on top of a mountain—that may be encountered in circumstances where the assumptions stated in the paper comply with reality. It is important in two ways. As a counter-intuitive scientific curiosity, it emphasizes that we must think long and hard to understand the ramifications of Nature's laws; and, as a prediction, it . . . [Full Text of this Article]


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