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JAC Advance Access originally published online on May 10, 2005
Journal of Antimicrobial Chemotherapy 2005 55(6):1051-1053; doi:10.1093/jac/dki155
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org

Correspondence

Is it necessary to change the classification of ß-lactamases?

Jean-Marie Frère1,*, Moreno Galleni1, Karen Bush2 and Otto Dideberg3

1 Centre d'Ingénierie des Protéines, Université de Liège, Belgium; 2 Johnson & Johnson Pharmaceutical Research & Development, LLC, Raritan, NJ 08869, USA; 3 Institut de Biologie Structurale Jean-Pierre Ebel (CNRS-CEA-UJF), F-38027 Grenoble, France

* Corresponding author. Email: jmfrere@ulg.ac.be

Keywords: ß-lactamases , classification , function , structure

The first 10% of the full text of this article appears below.

Sir,

ß-Lactamase classification schemes are inherently treacherous, particularly if one tries to take into account both structure and function. The decision to classify enzymes based on structure is the obvious way to describe these enzymes now that sequence data are so readily available. Most ß-lactamase investigators freely acknowledge that the first structural division of these enzymes involves the molecular separation of serine enzymes from metallo-ß-lactamases. Thus, it seems unnecessary to create a new classification nomenclature to acknowledge that fact.

If one decides that the classification of ß-lactamases should only rest on the comparison of the sequences, it is clear that Hall and Barlow have a point. The sequences of the B2 . . . [Full Text of this Article]


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