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JAC Advance Access originally published online on May 4, 2005
Journal of Antimicrobial Chemotherapy 2005 55(6):1050-1051; doi:10.1093/jac/dki130
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org

Correspondence

Revised Ambler classification of ß-lactamases

Barry G. Hall1,* and Miriam Barlow2

1 Biology Department, University of Rochester, Rochester, NY, USA; 2 Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA

* Corresponding author. Email: drbh@mail.rochester.edu

Keywords: ß-lactamases , classification , Ambler

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Sir,

ß-Lactamases are the primary cause of bacterial resistance to ß-lactam antibiotics. The most widely used classification of ß-lactamases is the Ambler classification1 that divides ß-lactamases into four classes (A, B, C and D) based upon their amino acid sequences. Ambler originally specified two classes: class A, the active-site serine ß-lactamases; and class B, the metallo-ß-lactamases that require a bivalent metal ion, usually Zn2+, for activity. Later a new class of serine ß-lactamases was found that bore . . . [Full Text of this Article]


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