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JAC Advance Access originally published online on February 22, 2005
Journal of Antimicrobial Chemotherapy 2005 55(4):587-590; doi:10.1093/jac/dki024
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions{at}oupjournals.org

Efficacy of micafungin against deep-seated candidiasis in cyclophosphamide-induced immunosuppressed mice

Mochiyoshi Ninomiya1, Hiroshige Mikamo1,2,*, Kaori Tanaka2, Kunitomo Watanabe2 and Teruhiko Tamaya1

1 Department of Obstetrics and Gynecology, Gifu University Graduate School of Medicine; 2 Division of Anaerobe Research, Life Science Research Center, Gifu University, 1-1 Yanagido, Gifu City, Gifu 501-1194, Japan

* Corresponding author. Tel: +81-58-230-6552; Fax: +81-58-230-6551; Email: mikamo{at}cc.gifu-u.ac.jp

Objectives: We investigated the effects of fluconazole and micafungin for the therapy of deep-seated candidiasis in a cyclophosphamide-induced immunosuppressed mouse model.

Methods: We used the experimental model of intraperitoneal fungal abscess caused by Candida albicans, as described previously.

Results and conclusions: Micafungin efficacy was equal to that of fluconazole in one-tenth dosage even in peritonitis. We also assessed the short-term (24 h) and long-term (8 days) therapeutic effects after the end of therapy. Although the therapeutic effect of fluconazole was similar to that of micafungin at 24 h after the end of therapy, the effect of micafungin was superior to that of fluconazole at 8 days after the end of therapy.

Keywords: micafungin , fluconazole , experimental infection , Candida albicans


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