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JAC Advance Access originally published online on December 1, 2004
Journal of Antimicrobial Chemotherapy 2005 55(1):131-132; doi:10.1093/jac/dkh502
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JAC vol.55 no.1 © The British Society for Antimicrobial Chemotherapy 2004; all rights reserved

Correspondence

Rapid detection of extended-spectrum ß-lactamase (ESBL)-producing organisms in blood culture

M. J. Weinbren* and M. A. Borthwick

Department of Microbiology, Coventry and Warwickshire Hospital, University Hospitals of Coventry and Warwickshire, Stoney Stanton Road, Coventry CV1 4FH, UK

Keywords: cefpodoxime , cefpodoxime–clavulanate , resistance , disc testing

The first 10% of the full text of this article appears below.

Sir,

Extended-spectrum ß-lactamases (ESBLs) have emerged as an important mechanism of resistance in Gram-negative bacteria. Unfortunately, ESBL-producing organisms often also possess resistance determinants to other important antibiotic groups, such as aminoglycosides and fluoroquinolones, leaving an extremely limited range of effective agents.1

Delay in appropriate therapy for infections with ESBL producers not only prolongs hospital stay, but is associated with increased mortality.2,3 Rapid detection of ESBL-producing organisms from blood culture could therefore be advantageous, aiding appropriate antibiotic choice at the earliest opportunity and improving outcomes.

The use . . . [Full Text of this Article]

* Corresponding author. Tel: +44-24-76844124; Fax: +44-24-76220081; Email: michael.weinbren@uhcw.nhs.uk


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