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JAC Advance Access originally published online on September 16, 2004
Journal of Antimicrobial Chemotherapy 2004 54(5):964-966; doi:10.1093/jac/dkh432
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JAC vol.54 no.5 © The British Society for Antimicrobial Chemotherapy 2004; all rights reserved

Correspondence

In vitro activity of daptomycin against enterococci from nosocomial and community environments in Portugal

C. Novais1, J. C. Sousa2, T. M. Coque3 and L. V. Peixe1,* on behalf of the Portuguese Resistance Study Group{dagger}

1 REQUINTE, Lab. Microbiologia, Faculdade de Farmácia, Universidade do Porto, Porto; 2 Microbiologia, Faculdade de Ciências da Saúde, Universidade Fernando Pessoa, Porto, Portugal; 3 Lab. de Microbiologia, Hospital Ramón y Cajal, Madrid, Spain

Keywords: cyclic lipopeptide antibiotics , clinical isolates , animal isolates , healthy volunteers , vancomycin-resistant enterococci

The first 10% of the full text of this article appears below.

Sir,

Daptomycin is a novel cyclic lipopeptide antibiotic with a unique mechanism of action that involves disruption of multiple aspects of the plasma membrane function without penetration into the cytoplasm. This antibiotic exhibits rapid concentration-dependent killing and the occurrence of spontaneous resistant mutants is rare. Although several studies have shown good in vitro and in vivo activity of daptomycin against clinical isolates of enterococci,1–5 . . . [Full Text of this Article]

* Corresponding author. Tel: +351-2-22078946; Fax: +351-2-2003977; Email: lpeixe@ff.up.pt


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