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JAC Advance Access originally published online on April 21, 2004
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Journal of Antimicrobial Chemotherapy (2004) 53, 1086-1089
© 2004 The British Society for Antimicrobial Chemotherapy

In vitro activity of terbinafine against medically important non-dermatophyte species of filamentous fungi

Guillermo Garcia-Effron, Alicia Gomez-Lopez, Emilia Mellado, Araceli Monzon, Juan L. Rodriguez-Tudela and Manuel Cuenca-Estrella*

Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ctra Majadahonda-Pozuelo Km 2, 28220 Majadahonda, Madrid, Spain

Received 18 November 2003; returned 16 December 2003; revised 23 December 2003; accepted 8 March 2004

Objectives: The activity in vitro of terbinafine against 442 clinical isolates of several species of filamentous fungi was analysed.

Methods: A broth microdilution test was carried out following the National Committee for Clinical Laboratory Standards reference method, with modifications described previously.

Results: The geometric mean (GM) of MICs of terbinafine for non-Aspergillus fumigatus species was 0.24 mg/L whereas the GM for A. fumigatus rose as far as 2.92 mg/L. Terbinafine showed a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L. However, some species such as Scedosporium spp., Fusarium spp., Scopulariopsis brevicaulis, and most of Mucorales exhibited high MICs of the allylamine with GMs >= 4 mg/L.

Conclusions: Overall, the GM of MICs of terbinafine was 1.57 mg/L, but significant differences in susceptibilities were seen between genera and species.

Keywords: Aspergillus spp., Spanish filamentous fungi, allylamines, antifungals

* Corresponding author. Tel: +34-91-5097961; Fax: +34-91-5097966; E-mail: mcuenca-estrella{at}isciii.es


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