JAC Advance Access originally published online on March 17, 2004
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Journal of Antimicrobial Chemotherapy (2004) 53, 713-728
© 2004 The British Society for Antimicrobial Chemotherapy
BSAC standardized disc susceptibility testing method (version 3)
Department of Microbiology, City Hospital NHS Trust, Birmingham B18 7QH, UK
Received 2 September 2003; accepted 16 December 2003
Keywords: breakpoints, disc testing, MICs
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Preface |
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Since the Journal of Antimicrobial Chemotherapy Supplement containing the BSAC standardized disc susceptibility testing method was published in 2001, there have been various changes to the recommendations and these have been posted on the BSAC website (http://www.bsac.org.uk). Two major organizational changes have been made to the interpretative tables. First is the separation of the acceptable ranges for the control strains from the interpretative criteria. The Working Party felt that it was appropriate to do this, as the control ranges are a tool for controlling the performance of the test and are not used for interpreting susceptibility. Second, in line with the European consensus, the presentation of MIC breakpoints (mg/L) has been amended as follows:
MIC 
(as previously) MIC breakpoint concentration = organism-susceptible
MIC > (previously 
) MIC breakpoint concentration = organism-resistant.
In practice, this does not make any changes to breakpoint systems based on two-fold dilutions, but it
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Introduction |
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Appendix 1. Amendments to the minimum inhibitory concentration and zone diameter breakpoints for ampicillin, amoxicillin and co-amoxiclav for interpreting the susceptibility of Enterobacteriaceae |
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Appendix 2. Review of the zone diameter breakpoints for piperacillin/tazobactam for interpreting the susceptibility of Enterobacteriaceae |
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Appendix 3. Advice on testing the susceptibility to co-trimoxazole is provided, however the following are the UK Committee on the Safety of Medicines (CSM) recommendations |
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Appendix 4. Susceptibility testing Haemophilus influenzae to ß-lactam antibiotics |
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