Skip Navigation


JAC Advance Access originally published online on February 18, 2004
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
53/4/620    most recent
dkh109v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (6)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Pérez-Trallero, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pérez-Trallero, E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


Journal of Antimicrobial Chemotherapy (2004) 53, 620-625
© 2004 The British Society for Antimicrobial Chemotherapy

Spectrum of antibiotic resistance of the Spain14-5 Streptococcus pneumoniae clone over a 22 year period

Emilio Pérez-Trallero1,2,*, José María Marimón1, Alberto Gonzalez1, Diego Vicente1 and José María García-Arenzana on behalf of The Spanish Pneumococcal Infection Study Network§

1 Microbiology Service, Hospital Donostia, Paseo Dr. Beguiristain s/n, 20014 San Sebastián (Gipuzkoa); 2 Department of Preventive Medicine and Public Health, Faculty of Medicine, University of the Basque Country, San Sebastián, Spain

Received 4 November 2003; returned 23 November 2003; revised 10 December 2003; accepted 11 December 2003

Objective: To study the characteristics and the evolution through time of a single Streptococcus pneumoniae multidrug-resistant international clone.

Methods: From 1981 to 2002, the presence of the multidrug-resistant Spain14-5 clone was studied among the 4201 S. pneumoniae isolated in Gipuzkoa (northern Spain).

Results: Overall, 93 isolates belonging to the Spain14-5 clone were identified. The first isolate of this clone was detected in 1981 and was already resistant to ß-lactams, erythromycin, clindamycin and chloramphenicol. The reference strain from the international collection for this clone was susceptible to macrolides and lincosamides whereas most of the isolates studied, including the first isolate detected in 1981, were resistant to macrolides and had the erm(B) gene encoding macrolide resistance.

Conclusions: The clone was genetically stable through time, was multiresistant since its inception and has recently become highly resistant to fluoroquinolones. The characteristic antibiotic resistance pattern of this clone should include erythromycin resistance.

Keywords: multiresistance, PFGE, MLST, fluoroquinolone resistance, macrolide resistance

* Corresponding author. Tel: +34-94-30-07046; Fax: +34-94-30-07063; E-mail: mikrobiol{at}terra.es

§ Participants in the Spanish Pneumococcal Infection Study Network are listed in the Acknowledgements.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Antimicrob. Agents Chemother.Home page
E. G. G. de la Pedrosa, M.-I. Morosini, M. van der Linden, P. Ruiz-Garbajosa, J. C. Galan, F. Baquero, R. R. Reinert, and R. Canton
Polyclonal Population Structure of Streptococcus pneumoniae Isolates in Spain Carrying mef and mef plus erm(B)
Antimicrob. Agents Chemother., June 1, 2008; 52(6): 1964 - 1969.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
P. Abgueguen, E. Azoulay-Dupuis, V. Noel, P. Moine, V. Rieux, B. Fantin, and J.-P. Bedos
Amoxicillin Is Effective against Penicillin-Resistant Streptococcus pneumoniae Strains in a Mouse Pneumonia Model Simulating Human Pharmacokinetics
Antimicrob. Agents Chemother., January 1, 2007; 51(1): 208 - 214.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
J. M. Marimon, E. Perez-Trallero, M. Ercibengoa, A. Gonzalez, A. Fenoll, and on behalf of the Spanish Pneumococcal Infection St
Molecular epidemiology and variants of the multidrug-resistant Streptococcus pneumoniae Spain14-5 international clone among Spanish clinical isolates
J. Antimicrob. Chemother., April 1, 2006; 57(4): 654 - 660.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
M. J. Ferrandiz, E. Perez-Trallero, J. M. Marimon, and A. G. de la Campa
Clinical Isolates of the Spain14-5 Clone of Streptococcus pneumoniae Carry a Recombinant rpoB Gene
Antimicrob. Agents Chemother., November 1, 2005; 49(11): 4811 - 4813.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.