JAC Advance Access originally published online on February 4, 2004
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Journal of Antimicrobial Chemotherapy (2004) 53, 544-545
© 2004 The British Society for Antimicrobial Chemotherapy
Correspondence |
Effect of the efflux pump inhibitor Phe-Arg-ß-naphthylamide on the MIC values of the quinolones, tetracycline and chloramphenicol, in Escherichia coli isolates of different origin
1 Área Bioquímica y Biología Molecular, Universidad de La Rioja, Logroño; 2 Servei de Microbiología, Institut Clínic d’Infeccions i Immunología, IDIBAPS, Hospital Clínic, Facultat de Medicina, Universitat de Barcelona, Barcelona; 3 Institut de Recerca Biomédica de Barcelona, Parc Científic de Barcelona, Universitat de Barcelona, Spain
Keywords: quinolone resistance, E. coli, GyrA, ParC
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Sir,
The main mechanisms of quinolone resistance in Escherichia coli include mutations in the gyrA and parC target genes and decreased intracellular accumulation.1 Active efflux pumps are important for intrinsic and acquired antibiotic resistance, and overexpression of efflux pumps affecting quinolones is becoming increasingly common in E. coli. Recently, efflux pump inhibitors have been investigated with a view to improving and potentiating the activity of exported antibiotics.2 Phe-Arg-ß-naphthylamide has been described as a broad-spectrum efflux pump inhibitor in Pseudomonas aeruginosa.2 The effect of this inhibitor on fluoroquinolone susceptibilities in Enterobacter aerogenes,3 E. coli
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