Skip Navigation


JAC Advance Access originally published online on December 19, 2003
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
53/2/277    most recent
dkh047v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (7)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Tumbarello, M.
Right arrow Articles by Cauda, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tumbarello, M.
Right arrow Articles by Cauda, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


Journal of Antimicrobial Chemotherapy (2004) 53, 277-282
© 2004 The British Society for Antimicrobial Chemotherapy

ESBL-producing multidrug-resistant Providencia stuartii infections in a university hospital

Mario Tumbarello1,*, Rita Citton1, Teresa Spanu2, Maurizio Sanguinetti2, Lucio Romano2, Giovanni Fadda2 and Roberto Cauda1

Departments of 1 Infectious Diseases and 2 Microbiology, Università Cattolica, Largo A. Gemelli 8, 00168 Roma, Italy

Received 18 August 2003; returned 1 October 2003; revised 30 October 2003; accepted 3 November 2003

Objectives: To investigate the epidemiological and clinical findings of extended-spectrum ß-lactamase (ESBL)-producing Providencia stuartii infections in a large Italian university hospital.

Patients and methods: All consecutive episodes of P. stuartii infection that occurred during 1999–2002 were included in the study. For each patient, we recorded the area of hospitalization and drug susceptibility of the P. stuartii strains. Patients with ESBL-producing P. stuartii infection were considered cases and those with non-ESBL-producing P. stuartii infection were used as controls.

Results: One hundred and sixteen (52%) out of 223 P. stuartii strains collected during the study period were found to be ESBL-producing. On the basis of PCR and DNA sequencing experiments, TEM-52 was identified in 87% of isolates and TEM-72 in 13%. All ESBL-producing P. stuartii infections were nosocomially acquired. The prevalence increased from 31% of P. stuartii infections in 1999 to 62% in 2002 (P = 0.04). All 116 strains were classified as ESBL-producing multidrug-resistant P. stuartii, since 88% of the isolates were cross-resistant to ciprofloxacin and amikacin and the other 12% were cross-resistant to ciprofloxacin and gentamicin. At logistic regression analysis, advanced age (P < 0.001), previous hospitalization (P < 0.01), neoplastic disease (P < 0.001) and previous antibiotic therapy (P < 0.001) were independent risk factors for the development of ESBL-producing infections.

Conclusions: This 4 year surveillance of Providencia complaints clearly indicates that infections caused by ESBL-producing multidrug-resistant P. stuartii are an emerging problem.

Keywords: Enterobacteriaceae, antibiotic resistance, nosocomial outbreak, P. stuartii, ESBLs

* Corresponding author. Tel: +39-06-30155373; Fax:+39-06-3054519; E-mail: tumbarello{at}rm.unicatt.it


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Antimicrob ChemotherHome page
V. Miriagou, L. S. Tzouvelekis, K. Flevari, M. Tsakiri, and E. E. Douzinas
Providencia stuartii with VIM-1 metallo-{beta}-lactamase
J. Antimicrob. Chemother., July 1, 2007; 60(1): 183 - 184.
[Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
M. Tumbarello, M. Sanguinetti, E. Montuori, E. M. Trecarichi, B. Posteraro, B. Fiori, R. Citton, T. D'Inzeo, G. Fadda, R. Cauda, et al.
Predictors of Mortality in Patients with Bloodstream Infections Caused by Extended-Spectrum-{beta}-Lactamase-Producing Enterobacteriaceae: Importance of Inadequate Initial Antimicrobial Treatment
Antimicrob. Agents Chemother., June 1, 2007; 51(6): 1987 - 1994.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
F. Luzzaro, M. Mezzatesta, C. Mugnaioli, M. Perilli, S. Stefani, G. Amicosante, G. M. Rossolini, and A. Toniolo
Trends in Production of Extended-Spectrum {beta}-Lactamases among Enterobacteria of Medical Interest: Report of the Second Italian Nationwide Survey.
J. Clin. Microbiol., May 1, 2006; 44(5): 1659 - 1664.
[Abstract] [Full Text] [PDF]

Home page
 J Med MicrobiolHome page
K. Shiroto, Y. Ishii, S. Kimura, J. Alba, K. Watanabe, Y. Matsushima, and K. Yamaguchi
Metallo-{beta}-lactamase IMP-1 in Providencia rettgeri from two different hospitals in Japan
J. Med. Microbiol., November 1, 2005; 54(11): 1065 - 1070.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
D. Aubert, T. Naas, M.-F. Lartigue, and P. Nordmann
Novel Genetic Structure Associated with an Extended-Spectrum {beta}-Lactamase blaVEB Gene in a Providencia stuartii Clinical Isolate from Algeria
Antimicrob. Agents Chemother., August 1, 2005; 49(8): 3590 - 3592.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.