Skip Navigation


JAC Advance Access originally published online on November 12, 2003
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
52/6/883    most recent
dkg490v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (8)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Einav, S.
Right arrow Articles by Glenn, J. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Einav, S.
Right arrow Articles by Glenn, J. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


Journal of Antimicrobial Chemotherapy (2003) 52, 883-886
© 2003 The British Society for Antimicrobial Chemotherapy

Leading Article

Prenylation inhibitors: a novel class of antiviral agents

Shirit Einav and Jeffrey S. Glenn*

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, CA 94305-5187, USA

Prenylation is a site-specific lipid modification of proteins. Although first described for a variety of cellular proteins, it has become apparent that viruses can also make use of this post-translational modification provided by their host cells. Depriving a virus access to prenylation can have dramatic effects on the targeted virus’s life cycle. Selective pharmacological inhibitors of prenylating enzymes have been developed and shown to have potent antiviral effects in both in vitro and in vivo systems. Because prenylation inhibitors target a host cell function, are available in oral form and are surprisingly well tolerated in human trials, these compounds represent an attractive new class of antiviral agents with potential for broad-spectrum activity. After a brief outline of host cell prenylation pathways, we review below the development of prenylation inhibition as an antiviral strategy applied to a prototype target, hepatitis delta virus (HDV), and discuss the potential application of prenylation inhibitors to a broad range of other viruses.

Keywords: farnesyltransferase inhibitors, hepatitis delta virus, antiviral therapy

* Corresponding author. Tel: +1-650-725-3373; Fax: +1-650-723-5488; E-mail: jeffrey.glenn{at}stanford.edu


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
Y. K. Peterson, P. Kelly, C. A. Weinbaum, and P. J. Casey
A Novel Protein Geranylgeranyltransferase-I Inhibitor with High Potency, Selectivity, and Cellular Activity
J. Biol. Chem., May 5, 2006; 281(18): 12445 - 12450.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
K. T. Lane and L. S. Beese
Thematic review series: Lipid Posttranslational Modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I
J. Lipid Res., April 1, 2006; 47(4): 681 - 699.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
P. T. K. Vietheer, H. J. Netter, T. Sozzi, and A. Bartholomeusz
Failure of the Lamivudine-Resistant rtM204I Hepatitis B Virus Mutants To Efficiently Support Hepatitis Delta Virus Secretion
J. Virol., May 15, 2005; 79(10): 6570 - 6573.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.