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JAC Advance Access originally published online on October 29, 2003
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Journal of Antimicrobial Chemotherapy (2003) 52, 1040-1042
© 2003 The British Society for Antimicrobial Chemotherapy

Ciprofloxacin-resistant Escherichia coli from bacteraemias in England; increasingly prevalent and mostly from men

David M. Livermore1,*, Tom Nichols2, Theresa L. Lamagni3, Nicola Potz1, Rosy Reynolds4 and Georgia Duckworth3

1 Antibiotic Resistance Monitoring & Reference Laboratory, Specialist & Reference Microbiology Division; 2 Statistics Unit and 3 Communicable Disease Surveillance Centre, Health Protection Agency, 61 Colindale Avenue, London NW9 5HT; 4 British Society for Antimicrobial Chemotherapy, 11 The Wharf, 16 Bridge Street, Birmingham B1 2JS, UK

Received 30 July 2003; returned 15 September 2003; revised 22 September 2003; accepted 23 September 2003

Objectives: To assess ciprofloxacin resistance among Escherichia coli isolates from bacteraemia patients in England in relation to age, sex and Region.

Methods: Routine susceptibility data for bacteraemia isolates were collected from over 90% of hospitals in England.

Results: During 1995–2001, the prevalence of ciprofloxacin resistance trebled, from 2.1% to 6.5%. Isolates from men were more frequently resistant than those from women, possibly because infections in men more often involve nosocomial strains. Resistance was rare (<1.5%) in isolates from patients aged <1 year; among older patients, resistance was unrelated to age in isolates from women, but peaked in the 15–44 age group for men.

Conclusions: The prevalence of ciprofloxacin resistance in E. coli from bacteraemia is strongly associated with sex and, to a lesser extent, age.

Keywords: E. coli, bacteraemia, gender, ciprofloxacin resistance

* Correspondence address. Antibiotic Resistance Monitoring & Reference Laboratory, Health Protection Agency—Colindale, 61 Colindale Avenue, London NW9 5HT, UK. Tel: +44-20-8200-4400; Fax: +44-20-8358-3292; E-mail: david.livermore{at}hpa.org.uk


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