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JAC Advance Access originally published online on September 12, 2003
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Journal of Antimicrobial Chemotherapy (2003) 52, 731
© 2003 The British Society for Antimicrobial Chemotherapy

Correspondence

Clarification of MPC and the mutant selection window concept

Xilin Zhao*

Public Health Research Institute, 225 Warren Street, Newark, NJ 07103, USA

Keywords: antimicrobial resistance, mechanism, limitation

The first 10% of the full text of this article appears below.

Sir,

Smith et al.1 recently warned that the newly emerged mutant prevention concentration (MPC) concept has been stretched beyond its limits. The authors correctly caution that when MPC is measured in a way that does not reflect the major mechanism of clinical resistance, it cannot be used in the clinical setting: one cannot determine the number of oranges in a barrel by counting apples. However, the title of the article and the table presented may confuse or even mislead . . . [Full Text of this Article]


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J. Antimicrob. Chemother., October 1, 2003; 52(4): 732 - 733.
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