JAC Advance Access originally published online on July 29, 2003
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Journal of Antimicrobial Chemotherapy (2003) 52, 525
© 2003 The British Society for Antimicrobial Chemotherapy
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Department of 1 Microbiology and 2 Internal Medicine, University Hospitals Leuven, Department of Microbiology, B-3000 Leuven, Belgium
Keywords: Streptococcus pneumoniae, breakthrough bacteraemia, macrolides, resistance
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Sir,
Our study1 is retrospective but not anecdotal. Our starting question was: what is the reason behind the failure of initial therapy in patients with invasive pneumococcal infection? In order to give any therapy a fair chance, our cut-off point was treatment for more than 48 h, which left