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JAC Advance Access originally published online on July 29, 2003
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Journal of Antimicrobial Chemotherapy (2003) 52, 524-525
© 2003 The British Society for Antimicrobial Chemotherapy

Correspondence

Significance of macrolide resistance in Streptococcus pneumoniae

Eric L. Nuermberger* and William R. Bishai

Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, 424 North Bond Street, Baltimore, MD 21231, USA

Keywords: Streptococcus pneumoniae, macrolides, clarithromycin, pneumococcal pneumonia, bacteraemia

The first 10% of the full text of this article appears below.

Sir,

We wish to comment on the paper by Van Kerkhoven et al.,1 to dispel certain misconceptions that may arise from a cursory review of their study. The authors present a 3 year retrospective chart review of patients hospitalized with pneumococcal bacteraemia at a single hospital. Of the 136 patients identified, 14 (10.3%) and 33 (24.3%) had isolates non-susceptible to penicillin and erythromycin, respectively. Of the erythromycin-resistant isolates, 94% had an MLSB-resistance phenotype and high-level erythromycin resistance (MIC > . . . [Full Text of this Article]


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