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JAC Advance Access originally published online on July 1, 2003
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Journal of Antimicrobial Chemotherapy (2003) 52, 303-305
© 2003 The British Society for Antimicrobial Chemotherapy

Susceptibility to rifaximin of Vibrio cholerae strains from different geographical areas

Maria Scrascia1, Maria Forcillo1, Francesco Maimone1,2 and Carlo Pazzani1,2,*

1 Dipartimento di Anatomia Patologica e di Genetica, Sezione di Genetica, Università di Bari, Via G. Amendola 165/A, 70126 Bari; 2 Interuniversity Research Centre for Sustainable Development, Università di Roma ‘La Sapienza’, Rome, Italy

Received 18 February 2003; returned 21 March 2003; revised 29 April 2003; accepted 6 May 2003

Four hundred and eight clinical strains of Vibrio cholerae isolated from different geographical areas and with different antimicrobial resistance patterns were tested for susceptibility to rifaximin, a non-absorbable antibiotic active in vitro against Gram-negative bacteria. The MICs ranged from 0.5 to 4 mg/L for all strains. These values and the pharmacokinetic properties suggest rifaximin as an attractive antimicrobial agent for cholera.

Keywords: rifamycin derivative, antimicrobial activity, cholera

* Corresponding author. Fax: +39-080-544-3386; E-mail: pazzani{at}biologia.uniba.it.


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