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JAC Advance Access originally published online on July 1, 2003
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Journal of Antimicrobial Chemotherapy (2003) 52, 155-158
© 2003 The British Society for Antimicrobial Chemotherapy

Leading Article

Thymic involvement in recovery of immunity among HIV-infected adults on highly active antiretroviral therapy

Rafael de la Rosa and Manuel Leal*

Viral Hepatitis and AIDS Study Group, Department of Internal Medicine, Virgen del Rocío University Hospital, Avda. Manuel Siurot s/n., 41013 Seville, Spain

Keywords: thymus, HIV, HAART, recovery of immunity

The first 150 words of the full text of this article appear below.


   Introduction
 
Human immunodeficiency virus (HIV) infection is characterized by a decrease in both function and number of CD4 T cells, associated with viral replication and failure of homeostatic mechanisms involved in regeneration of immunity. The objective of highly active antiretroviral therapy (HAART) is to suppress HIV replication and achieve recovery of immunity in HIV-infected patients. This potent antiretroviral therapy allows successful suppression of HIV replication, with undetectable plasma HIV RNA levels being reached in the vast majority of patients on treatment. However, the degree of CD4 T cell repopulation induced by HAART is very heterogeneous between different patients,1 and depends on several host and virological factors.2

Previous studies and reviews have described broadly the characteristics of recovery of immunity in HIV-infected adults on HAART.1,2 Biphasic kinetics of CD4 cell repopulation following HAART have been proposed: an early increase phase associated with cellular redistribution from lymph nodes, and a later phase characterized . . . [Full Text of this Article]


   Evidence of thymic involvement in HIV-infected patients on HAART
 

   Thymic function-related markers
 
Thymic volume

TREC-bearing cells

Naive T cell subsets


   Strategies in the setting of thymus-dependent recovery of immunity
 

   Conclusions
 

   Acknowledgements
 

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S. Resino, A. Perez, J. A. Leon, M. D. Gurbindo, and M. A. Munoz-Fernandez
Interleukin-7 levels before highly active antiretroviral therapy may predict CD4+ T-cell recovery and virological failure in HIV-infected children
J. Antimicrob. Chemother., April 1, 2006; 57(4): 798 - 800.
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