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JAC Advance Access originally published online on May 13, 2003
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Journal of Antimicrobial Chemotherapy (2003) 51, 1436-1437
© 2003 The British Society for Antimicrobial Chemotherapy

Correspondence

Bacteraemia due to Bacteroides fragilis with reduced susceptibility to metronidazole

A. A. F. Elsaghier1,*, J. S. Brazier2 and E. A. James1

1 Barnet and Chase Farm Hospitals NHS Trust, Department of Medical Microbiology, Wellhouse Lane, Barnet, Herts EN5 3DJ; 2 Anaerobe Reference Unit, Department of Medical Microbiology and Public Health Laboratory, University Hospital of Wales, Heath Park, Cardiff CF14 4XW, UK

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Sir,

Surveys of antimicrobial susceptibilities of isolates of the Bacteroides fragilis group showed that isolates were usually susceptible to metronidazole.1 Metronidazole-resistant phenotypes have rarely been reported. Here we report B. fragilis bacteraemia with reduced susceptibility to metronidazole developing during treatment.

A 70-year-old man was admitted for excision of rectal adenoma. Prophylaxis with intravenous cefuroxime (750 mg/8 h) and intravenous metronidazole (500 . . . [Full Text of this Article]


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