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JAC Advance Access originally published online on April 25, 2003
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Journal of Antimicrobial Chemotherapy (2003) 51, 1419-1422
© 2003 The British Society for Antimicrobial Chemotherapy

In vitro susceptibility of Aspergillus spp. clinical isolates to albendazole

N. Berthet1, O. Faure2, A. Bakri3, P. Ambroise-Thomas1,2, R. Grillot1,2 and J.-F. Brugère1,*

1 Laboratoire ‘Interactions Cellulaires Parasite-Hôte’ ICPH, Faculté de Médecine et Pharmacie, Université Joseph Fourier, F-38706 La Tronche; 2 Service de Parasitologie-Mycologie, CHU, BP217, F-38043 Grenoble; 3 Formulation et ingénierie pharmaceutique, Code GEPRA, INSERM 008, Faculté de Pharmacie, Université Joseph Fourier, F-38706 La Tronche, France

Received 25 October 2002; returned 1 December 2002; revised 31 January 2003; accepted 12 March 2003

The in vitro antifungal activity of albendazole, a benzimidazole widely used as an antihelmintic drug in humans, was investigated and assessed for its activity against Aspergillus spp. Forty-eight isolates, representing the most frequent species found in human pathology [Aspergillus fumigatus (n = 27), Aspergillus flavus (n = 10), Aspergillus terreus (n = 7), Aspergillus nidulans (n = 3) and Aspergillus niger (n = 1)], and one quality control strain (A. niger ATCC 9804 83435) were tested according to the NCCLS M38-P methodology for moulds. All the strains were susceptible to albendazole, with homogeneous MICs for each species; three strains were resistant to itraconazole.

Keywords: drug susceptibility, benzimidazole, antifungal

* Corresponding author. Tel: +33-476-637473; Fax: +33-476-637473; E-mail: Jean-Francois.Brugere{at}ujf-grenoble.fr


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