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JAC Advance Access originally published online on April 14, 2003
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Journal of Antimicrobial Chemotherapy (2003) 51, 1307-1308
© 2003 The British Society for Antimicrobial Chemotherapy


Correspondence

Reply to: Efficacy and pharmacodynamics of simulated human-like treatment with levofloxacin on experimental pneumonia induced with penicillin-resistant pneumococci with various susceptibilities to fluoroquinolones

Ethan Rubinstein*

Infectious Diseases Unit, Sheba Medical Center, Tel Aviv University Faculty of Medicine, Tel Hashomer 52621, Israel

Keywords: levofloxacin, Streptococcus pneumoniae, pneumonia, model

The first 10% of the full text of this article appears below.

Sir,

Croisier et al.1 described an experimental model of pneumococcal pneumonia in the rabbit caused by penicillin-resistant Streptococcus pneumoniae with different susceptibilities to fluoroquinolones. In this model, levofloxacin, at a dose that simulated human treatment with 500 mg twice a day, was effective against strains with levofloxacin MIC < 1.5 mg/L, but ineffective against strains . . . [Full Text of this Article]


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D. Croisier, M. Etienne, and P. Chavanet
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J. Antimicrob. Chemother., May 1, 2003; 51(5): 1308 - 1309.
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