JAC Advance Access originally published online on February 25, 2003
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Journal of Antimicrobial Chemotherapy (2003) 51, 1037-1039
© 2003 The British Society for Antimicrobial Chemotherapy
Correspondence |
Interaction of plasmid and host quinolone resistance
1 Department of Microbiology, School of Medicine, University of Seville, Seville, Spain; 2 Lahey Clinic, Burlington, MA; 3 VA Medical Center, Bedford, MA, USA
Keywords: fluoroquinolone, antimicrobial, Klebsiella pneumoniae, Escherichia coli
| The first 10% of the full text of this article appears below. |
Sir,
Resistance to quinolones in Gram-negative bacteria is usually caused by chromosomal mutations that alter the target enzymes DNA gyrase and topoisomerase IV or activate the efflux systems that pump the drugs out of the cytoplasm. Loss of porin channels for drug entry may also contribute to resistance, but is less important. Plasmid-mediated quinolone resistance, long thought not to exist, has recently been discovered.1 Conjugative plasmid pMG252, found in a
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