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JAC Advance Access originally published online on February 25, 2003
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Journal of Antimicrobial Chemotherapy (2003) 51, 1025-1028
© 2003 The British Society for Antimicrobial Chemotherapy

Microbiological efficacy of ABT-773 (cethromycin) for the treatment of community-acquired pneumonia due to Chlamydia pneumoniae

Margaret R. Hammerschlag1,*, Tamara Reznik1, Patricia M. Roblin1, Julio Ramirez2, James Summersgill2 and Stanley Bukofzer3

1 Departments of Pediatrics and Medicine, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York, NY 11203-2098; 2 Department of Medicine, University of Louisville, Louisville, KY; 3 Abbott Laboratories, 200 Abbott Park Road, Abbott Park, IL, USA

Received 22 October 2002; returned 13 December 2002; revised 24 December 2002; accepted 15 January 2003

Nasopharyngeal specimens for culture of Chlamydia pneumoniae were obtained from patients with community-acquired pneumonia enrolled in a randomized study comparing the novel ketolide antibiotic ABT-773 at a dose of 150 mg once a day to 150 mg twice a day, by mouth for 10 days. C. pneumoniae was eradicated from the nasopharynx of 10 of 10 (100%) microbiologically evaluable patients. MICs and MBCs for 13 isolates of C. pneumoniae from 12 patients obtained before and after therapy were performed against ABT-773. The MIC90 and MBC90 of ABT-773 were 0.015 mg/L.

Keywords: chlamydia, C. pneumoniae, ketolide

* Corresponding author. Tel: +1-718-270-3097; Fax: +1-718-270-1985; E-mail: mhammerschlag{at}pol.net


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