JAC Advance Access originally published online on February 11, 2003
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Journal of Antimicrobial Chemotherapy (2003) 51, 739-740
© 2003 The British Society for Antimicrobial Chemotherapy
Correspondence |
Mu50 glycopeptide-resistant Staphylococcus aureus: the case of the missing penicillinase
Department of Microbiology, South Tyneside District Hospital, South Shields, Tyne and Wear, UK
Keywords: Mu50 Staphylococcus aureus, GISA, penicillinase, ß-lactamase
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Sir,
Mu50 glycopeptide-resistant Staphylococcus aureus, first described by Hiramatsu et al.,1 remains the prototype of an increasing number of intermediately susceptible strains of S. aureus. The mode of resistance has yet to be completely described, but seems to be mediated by abnormalities in cell-wall synthesis, with incomplete transamidation of peptidoglycan possibly being important.2,3 The organism is known to be methicillin resistant, but in all the literature pertaining to this organism,
Acknowledgements