Skip Navigation


JAC Advance Access originally published online on January 28, 2003
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
51/3/715    most recent
dkg106v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (12)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Pérez-Trallero, E.
Right arrow Articles by Iglesias, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pérez-Trallero, E.
Right arrow Articles by Iglesias, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


Journal of Antimicrobial Chemotherapy (2003) 51, 715-719
© 2003 The British Society for Antimicrobial Chemotherapy

Spain14-5 international multiresistant Streptococcus pneumoniae clone resistant to fluoroquinolones and other families of antibiotics

Emilio Pérez-Trallero1,2,*, José M. Marimón1, Alberto Gonzalez1 and Luis Iglesias1

1 Servicio de Microbiología, Hospital Donostia, Paseo Dr. Beguiristain s/n, 20014 San Sebastián (Gipuzkoa); 2 Departamento de Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad del País Vasco, San Sebastián, Spain

Received 17 October 2002; returned 20 November 2002; revised 25 November 2002; accepted 26 November 2002

The Spain14-5 international multiresistant clone was initially described as resistant to penicillin, tetracycline, chloramphenicol and trimethoprim/sulfamethoxazole. In Gipuzkoa, Spain, Streptococcus pneumoniae isolated from 16 patients, and determined by PFGE and multilocus sequence typing to belong to the Spain14-5 clone, showed further resistance to fluoroquinolones (all strains had point mutations in the parC and gyrA genes). In addition, most strains showed resistance to amoxicillin (MIC >= 8 mg/L), cefotaxime (MIC >= 2 mg/L), macrolides and lincosamides. Two strains were resistant to rifampicin (MIC 8 mg/L). The multiresistance observed in these isolates converts the Spain14-5 clone into one of the most, if not the most, multiresistant of the international clones described.

Keywords: rifampicin resistance, erythromycin resistance, mechanism of resistance

* Corresponding author. Tel: +34-94-300-7046; Fax: +34-94-300-7063; E-mail: mikrobiol{at}terra.es


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Antimicrob. Agents Chemother.Home page
M. J. Ferrandiz, E. Perez-Trallero, J. M. Marimon, and A. G. de la Campa
Clinical Isolates of the Spain14-5 Clone of Streptococcus pneumoniae Carry a Recombinant rpoB Gene
Antimicrob. Agents Chemother., November 1, 2005; 49(11): 4811 - 4813.
[Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
R. R. Reinert, S. Reinert, M. van der Linden, M. Y. Cil, A. Al-Lahham, and P. Appelbaum
Antimicrobial Susceptibility of Streptococcus pneumoniae in Eight European Countries from 2001 to 2003
Antimicrob. Agents Chemother., July 1, 2005; 49(7): 2903 - 2913.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
M. J. Ferrandiz, C. Ardanuy, J. Linares, J. M. Garcia-Arenzana, E. Cercenado, A. Fleites, A. G. de la Campa, and the Spanish Pneumococcal Infection Study Network
New Mutations and Horizontal Transfer of rpoB among Rifampin-Resistant Streptococcus pneumoniae from Four Spanish Hospitals
Antimicrob. Agents Chemother., June 1, 2005; 49(6): 2237 - 2245.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
M. W. R. Pletz, L. McGee, J. Jorgensen, B. Beall, R. R. Facklam, C. G. Whitney, and K. P. Klugman
Levofloxacin-Resistant Invasive Streptococcus pneumoniae in the United States: Evidence for Clonal Spread and the Impact of Conjugate Pneumococcal Vaccine
Antimicrob. Agents Chemother., September 1, 2004; 48(9): 3491 - 3497.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
E. Perez-Trallero, J. M. Marimon, A. Gonzalez, D. Vicente, J. M. Garcia-Arenzana, and on behalf of The Spanish Pneumococcal Infection St
Spectrum of antibiotic resistance of the Spain14-5 Streptococcus pneumoniae clone over a 22 year period
J. Antimicrob. Chemother., April 1, 2004; 53(4): 620 - 625.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
R. Canton, M. Morosini, M. C. Enright, and I. Morrissey
Worldwide incidence, molecular epidemiology and mutations implicated in fluoroquinolone-resistant Streptococcus pneumoniae: data from the global PROTEKT surveillance programme
J. Antimicrob. Chemother., December 1, 2003; 52(6): 944 - 952.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
E. Perez-Trallero, J. M. Marimon, A. Gonzalez, C. Garcia-Rey, and L. Aguilar
Genetic Relatedness of Recently Collected Spanish Respiratory Tract Streptococcus pneumoniae Isolates with Reduced Susceptibility to Amoxicillin
Antimicrob. Agents Chemother., November 1, 2003; 47(11): 3637 - 3639.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.