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JAC Advance Access originally published online on January 6, 2003
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Journal of Antimicrobial Chemotherapy (2003) 51, 435-438
© 2003 The British Society for Antimicrobial Chemotherapy

Antimycobacterial activity of diospyrin derivatives and a structural analogue of diospyrin against Mycobacterium tuberculosis in vitro

N. Lall1, M. Das Sarma2, B. Hazra2 and J. J. M. Meyer1,*

1 Department of Botany, University of Pretoria, Pretoria 0002, South Africa; 2 Department of Pharmaceutical Technology, Jadavpur University, Calcutta-700032, India

Received 16 April 2002; returned 15 August 2002; revised 16 October 2002. accepted 24 October 2002

Three derivatives and one structural analogue of diospyrin were synthesized and investigated for their inhibitory activity against Mycobacterium tuberculosis employing the rapid radiometric method in vitro. A novel aminoacetate derivative was found to be more active than the parent compound, the MICs being 50 and 100 mg/L, respectively, for a drug-susceptible strain, H37Rv, of M. tuberculosis. This derivative also exhibited an MIC of 50 mg/L for a few multidrug-resistant strains of M. tuberculosis. The other two derivatives and the analogue did not show any significant antimycobacterial activity at the highest concentration (100 mg/L) tested.

* Corresponding author. Tel: +27-12-4202224; Fax: +27-12-3625099; E-mail: marion{at}scientia.up.ac.za


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[Abstract] [Full Text] [PDF]


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