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JAC Advance Access originally published online on January 6, 2003
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Journal of Antimicrobial Chemotherapy (2003) 51, 427-429
© 2003 The British Society for Antimicrobial Chemotherapy

Growing antimicrobial resistance of Shigella isolates

Shai Ashkenazi1,3,*, Itzhak Levy2,4, Vered Kazaronovski5 and Zmira Samra4,5

1 Department of Paediatrics A and 2 Unit of Infectious Diseases, Schneider Children’s Medical Center of Israel, 14 Kaplan Street, Petah Tiqva 49202; 3 Felsenstein Medical Research Centre, Petah Tiqva; 4 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; 5 Department of Clinical Microbiology, Rabin Medical Center, Petah Tiqva, Israel

Received 19 July 2002; returned 26 September 2002; revised 6 November 2002; accepted 7 November 2002

Appropriate antibiotic treatment of shigellosis depends on identifying resistance patterns. By studying Shigella isolates in central Israel from 1998 to 2000, and comparing with the period 1991–1992, we identified a significantly increased resistance to tetracycline (from 23% to 87%, P < 0.00001), high resistance to trimethoprim–sulfamethoxazole (94%) and ampicillin (85%) and emerging resistance to quinolones (0.5–2%). These data mandate local monitoring of resistance and its consideration in empirical therapy.

Keywords: diarrhoea, shigellosis, antibiotic therapy

* Corresponding author. Tel: +972-3-9253680; Fax: +972-3-9253056; E-mail: ashai{at}post.tau.ac.il


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