JAC Advance Access originally published online on November 28, 2002
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Journal of Antimicrobial Chemotherapy (2003) 51, 202-203
© 2003 The British Society for Antimicrobial Chemotherapy
Correspondence |
Disseminated oxacillin-resistant Staphylococcus aureus infection responsive to vancomycin and quinupristindalfopristin combination therapy
1 Section on Infectious Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157; 2 Department of Pharmacy, Wake Forest University Baptist Medical Center, Winston-Salem, NC, USA
Keywords: disseminated, oxacillin-resistant Staphylococcus aureus
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Sir,
We describe a case with oxacillin-resistant Staphylococcus aureus (ORSA) bacteraemia with associated polyarticular septic arthritis, soft-tissue abscesses, vertebral osteitis and discitis. Although the ORSA isolates were susceptible to vancomycin (VAN), bacteraemia, fever and leucocytosis persisted while on treatment with VAN, rifampicin and gentamicin but resolved with combination treatment of VAN and quinupristindalfopristin (Q-D).
In April 2002, a 67-year-old female with a history of gout presented to the emergency department (ED) with pain and swelling of the right great toe with
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