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JAC Advance Access originally published online on November 28, 2002
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Journal of Antimicrobial Chemotherapy (2003) 51, 163-166
© 2003 The British Society for Antimicrobial Chemotherapy

Antifungal activity of the echinocandin anidulafungin (VER002, LY-303366) against yeast pathogens: a comparative study with M27-A microdilution method

María Pilar Arévalo1,*, Alfonso-Javier Carrillo-Muñoz2, Javier Salgado1,3, Delia Cardenes1, Sonia Brió2, Guillermo Quindós4 and Ana Espinel-Ingroff5

1 Cátedra de Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de la Laguna, 38071 La Laguna, Tenerife; 2 Departamento de Microbiología, ACIA, Barcelona; 3 Hospital Ntra. Sra. de Candelaria, Tenerife; 4 Departamento de Immunología, Microbiología y Parasitología, Facultad de Medicina, Universidad del País Vasco, Bilbao, Spain; 5 Medical College of Virginia, Campus Virginia Commonwealth University, Richmond, VA, USA

Received 18 December 2001; returned 4 June 2002; revised 15 July 2002; accepted 28 September 2002

This study further evaluated the in vitro activity of anidulafungin (VER002, Versicor Inc.) (LY303366) against 460 clinical yeast isolates. MICs of anidulafungin, fluconazole and itraconazole were determined by following the NCCLS M27-A guidelines. Minimum fungicidal concentrations (MFCs) of anidulafungin were determined for 230 isolates of Candida spp. The activity of anidulafungin in vitro was significantly superior (P < 0.05) to those of itraconazole and fluconazole against Candida albicans, Candida tropicalis, Candida glabrata and Candida krusei, but anidulafungin was less active for Candida famata and Candida parapsilosis. The differences were not significant for the other species evaluated.

* Corresponding author. Tel: +34-922-319-376; Fax: +34-922-319-378; E-mail: mpareval{at}ull.es


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