JAC Advance Access originally published online on October 22, 2002
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Journal of Antimicrobial Chemotherapy (2002) 50, 743-746
© 2002 The British Society for Antimicrobial Chemotherapy
Linezolid-resistant enterococci: report of the first isolates in the United Kingdom
1 Southampton Public Health Laboratory, Southampton General Hospital, Southampton SO16 6YD; 2 Chelmsford Public Health Laboratory; 3 Department of Microbiology, Hammersmith Hospital; 4 Laboratory of Hospital Infection, Central Public Health Laboratory, Colindale, London; 5 Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, Colindale, London, UK
Received 12 June 2002; returned 18 August 2002; revised 11 September 2002; accepted 13 September 2002
Linezolid, the first oxazolidinone antibacterial agent to be developed for clinical use, was licensed in the UK in early 2001. We report the first three examples of resistant enterococci (two isolates of Enterococcus faecium and one Enterococcus faecalis) isolated in the UK, which were obtained from patients who had received linezolid. The linezolid MICs for the resistant isolates were 64 mg/L. Pulsed-field gel electrophoresis (PFGE) analysis of the linezolid-susceptible and -resistant isolates from two of the patients, combined with sequence analysis of rRNA, indicated that resistance developed in previously susceptible strains, most probably via a point mutation in the 23S rRNA.
Keywords: linezolid, resistance, enterococci
* Corresponding author. Tel: +44-23-8079-6084; Fax: +44-23-8079-2530; E-mail: cressida{at}doctors.org.uk
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