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JAC Advance Access originally published online on October 8, 2002
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Journal of Antimicrobial Chemotherapy (2002) 50, 625-627
© 2002 The British Society for Antimicrobial Chemotherapy

Leading articles

Probiotics in human infections

Å. Sullivan and C. E. Nord*

Department of Microbiology, Pathology and Immunology, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden

Keywords: probiotics, human infections

The first 10% of the full text of this article appears below.

At the beginning of the last century, the Russian immunologist Elie Metchnikoff argued that life-long intake of yoghurt containing lactic acid-producing microorganisms could explain the differences in length of life between ethnic groups. The idea was that the bacteria in the fermented products competed with microorganisms that are injurious to health.1 Today it is known that the normal human microflora is important as a barrier against colonization by exogenous pathogenic microorganisms and potentially pathogenic bacteria already present in small numbers in the microflora.2 The normal microflora influence several biochemical, physiological and immunological features of the host, particularly the gastrointestinal flora, which consists of the most dense and diverse collection of bacteria.3 Disturbances in the normal microflora can be caused by several things, one being the administration of antimicrobial agents.4 Probiotic . . . [Full Text of this Article]


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