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Journal of Antimicrobial Chemotherapy (2002) 50, 429-432
© 2002 The British Society for Antimicrobial Chemotherapy

Free and total cefazolin plasma and interstitial fluid concentrations at steady state during continuous infusion

Grant W. Howard1, Evan J. Begg1, Stephen T. Chambers2, Jane Vella Brincat1,*, Mei Zhang1 and Carl M. J. Kirkpatrick1

Departments of 1 Clinical Pharmacology and 2 Infectious Diseases, Christchurch Hospital, PO Box 4710, Christchurch, New Zealand

Received 7 December 2001; returned 13 March 2002; revised 15 May 2002; accepted 25 May 2002

Free and total concentrations of cefazolin were compared in plasma and interstitial fluid during continuous intravenous infusion therapy. Seven patients, median age 53 (25–74) years, were administered a constant infusion of cefazolin at a mean (±S.D.) dose of 3.5 g (±1.1) per 24 h for >=5 days. Four blisters were induced on the forearm of each patient for sampling of interstitial fluid. Free concentrations in plasma and interstitial fluid were similar, and correlated better than total concentrations (r2 = 0.82, P = 0.005 versus r2 = 0.54, P = 0.056). In all patients, the free concentrations in the interstitial fluid were at least two-fold the MIC90 for Staphylococcus aureus.

* Corresponding author. Tel: +64-3-3640640; Fax: +64-3-3641003; E-mail: jane.vella-brincat{at}cdhb.govt.nz


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