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Journal of Antimicrobial Chemotherapy (2002) 50, 361-364
© 2002 The British Society for Antimicrobial Chemotherapy

Zeamatin, clotrimazole and nikkomycin Z in therapy of a Candida vaginitis model

David A. Stevens1,2,3,*, Leilani Calderon3, Martha Martinez3, Karl V. Clemons1,2,3, Shelly J. Wilson4 and Claude P. Selitrennikoff4,5

1 Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA; 2 Division of Infectious Diseases and Geographic Medicine, Stanford University Medical School, Stanford, CA 94305; 3 California Institute for Medical Research, San Jose, CA 95128; 4 MycoLogics Inc., Denver, CO 80262; 5 Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver, CO 80262, USA

Received 2 August 2001; returned 19 November 2001; revised 17 May 2002; accepted 31 May 2002

Objective: To study the interaction of antifungal drugs in topical therapy.

Materials and methods: Local therapy of Candida vaginitis with drugs alone and in combination was examined in a murine model. Zeamatin, a natural plant-derived antifungal protein, was tested alone and in combination with an azole, clotrimazole or nikkomycin Z, a chitin synthase inhibitor.

Results: Whereas alone, zeamatin was ineffective, nikkomycin Z was effective only when dosed multiple times per day, and clotrimazole efficacy was variable when administered in experimental vehicles (unlike the complex and undefined commercial preparation), zeamatin enhanced the efficacy of either of the other two drugs when they were given in combination.

Conclusion: Drug interactions between novel drugs with unique mechanisms of action should be explored further, and may lead to more potent regimens.

* Correspondence address. Department of Medicine, Santa Clara Valley Medical Center, 751 South Bascom Avenue, San Jose, CA 95128-2699, USA. Tel: +1-408-885-4313; Fax: +1-408-885-4306; E-mail: stevens{at}stanford.edu


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