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Journal of Antimicrobial Chemotherapy (2002) 50, 309-311
© 2002 The British Society for Antimicrobial Chemotherapy

Leading article

HIV-1 in peripheral blood monocytes: an underrated viral source

Tuofu Zhu*

Department of Laboratory Medicine, University of Washington School of Medicine, Box 358070, 960 Republican Street, Seattle, WA 98109-8070, USA

The first 150 words of the full text of this article appear below.


   Evidence for HIV-1 persistence and replication in peripheral blood monocytes
 
Mononuclear phagocytes can be divided into two groups: the circulating mononuclear phagocytes, or monocytes, in the peripheral blood and the tissue macrophages in organs such as the spleen, lymph nodes, liver (Kupffer cells), the lung (alveolar macrophages), brain (microglial cells) and intestine. Tissue macrophages originate from circulating blood monocytes, and monocytes in turn are generated from precursor cells in the bone marrow. Peripheral blood monocytes are heterogeneous in size, morphology and cell-surface molecule expression, each of which serve as parameters for isolating and defining monocytes.1 In the earliest studies monocytes were isolated by gradient centrifugation and counterflow centrifugation (elutriation), which allowed for the separation of monocyte subsets by size and density. Adherence of peripheral blood mononuclear cells (PBMC) has also been used to generate monocytes and monocyte-derived macrophages (MDM). In recent years the combination of beads conjugated to monoclonal antibodies and flow cytometry has provided a powerful tool to purify . . . [Full Text of this Article]


   Models of HIV-1 persistence and replication in peripheral blood monocytes
 

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