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Journal of Antimicrobial Chemotherapy (2002) 50, 257-259
© 2002 The British Society for Antimicrobial Chemotherapy

Enhanced contact activity of fluconazole in association with antioxidants against fluconazole-resistant organisms

G. Simonetti, A. Villa and N. Simonetti*

University of Rome ‘La Sapienza’, Institute of Microbiology, Faculty of Pharmacy, Piazzale Aldo Moro 5, 00185 Rome, Italy

Received 8 May 2001; returned 28 December 2001; revised 12 April 2002; accepted 26 April 2002

Fluconazole alone does not demonstrate any contact activity against resistant organisms. Phenolic antioxidants, such as butylated hydroxyanisole, appear to promote fluconazole activity resulting in the killing of 104 cfu/mL of 11 resistant Candida albicans strains within 3–15 min and of 104 cfu/mL of 10 resistant Escherichia coli strains within 6–15 min. Fluconazole activity was increased by the addition of ethyl alcohol (20%). Antioxidants appear to promote fluconazole activity by increasing cell membrane permeability. This combination has potential advantages in the administration of topical fluconazole.

* Corresponding author. Tel: +39-06-4468622; Fax: +39-06-4468625; E-mail: nicola.simonetti{at}uniroma1.it


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